Carbamylation of vimentin is inducible by smoking and represents an independent autoantigen in rheumatoid arthritis
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چکیده
منابع مشابه
Carbamylation of vimentin is inducible by smoking and represents an independent autoantigen in rheumatoid arthritis
OBJECTIVES Smoking has been connected to citrullination of antigens and formation of anti-citrullinated peptide antibodies (ACPAs) in rheumatoid arthritis (RA). Since smoking can modify proteins by carbamylation (formation of homocitrulline), this study was conducted to investigate these effects on vimentin in animal models and RA. METHODS The efficiency of enzymatic carbamylation of vimentin...
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The discovery that citrullination was crucial for the recognition of antigens by the most disease-specific class of autoantibodies in rheumatoid arthritis (RA) had a huge impact on studies aimed at understanding autoimmunity in this disease. In addition to the detailed characterization of anti-citrullinated protein antibodies, various studies have addressed the identity of citrullinated antigen...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2017
ISSN: 0003-4967,1468-2060
DOI: 10.1136/annrheumdis-2016-210059